ESoothe™ Ultra

ESoothe™ Ultra

Vitamin E Suppositories 100 IU

Vaginal Moisturizer

$23.90
$23.90
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When you need more, we made more. ESoothe Ultra delivers 100 IU of natural vitamin E to support moisture and tissue comfort, 2.5x more than our original. One insert a day is all you need. Gentle, hormone-free, and clean by design.

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  • All Natural
  • Made in USA
  • Gentle Formula
Size

Trusted by Over 1 Million Women for Women’s Wellness

Is This For You?

You may benefit from ESoothe Inserts if you:

  • Experience vaginal dryness
  • Want a hormone-free way to support intimate moisture
  • Want to feel more comfortable during intimacy

Benefits

  • 100 IU of natural vitamin E - 2.5x our original formula
  • Supports moisture and tissue comfort
  • Hormone-free and naturally derived
  • Clean, plant-based formula — no PEGs, parabens, or GMOs

Ingredients

Vitamin E (d-alpha tocopheryl acetate), hydrogenated palm kernel oil.

Hormone-free, non-GMO, paraben-free, zero trans fats, with no PEGs or synthetic carriers. Never made with partially hydrogenated oils.

How to Use

While lying down, gently insert one suppository vaginally with finger at bedtime. Use 3-5 days per work, as needed. Do not use more than one suppository per day.

Safety & Precautions

For vaginal use only. Discontinue if irritation persists. Consult your healthcare provider before use if pregnant, breastfeeding, or managing a medical condition. Store at room temperature, away from heat and sunlight.

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  • 1M+

    Women Supported Nationwide

  • 30K+

    Reviews

  • 1000+

    Practitioners And Growing

For the women who want more

The support your body's been asking for.

Dryness. Discomfort. That quiet feeling of this isn't how it used to be. It's more common than anyone talks about, and it doesn't have to be your new normal.

Made for you if

You know your body, and you know what you want.

ESoothe Ultra was made for women who aren't just looking for the basics. It's our strongest vitamin E insert, designed for meaningful, nourishing support.

  • You've tried basic moisturizers and want stronger support
  • You prefer plant-based, hormone-free options
  • You want vitamin E at the dose used in clinical research
  • You want to know exactly what you're putting in your body

2.5x Stronger

100IU

Of natural vitamin E per insert.

The same dose studied in clinical research on vaginal vitamin E suppositories. That's 2.5x more than our original formula. Because you deserve more than baseline.

WHY IT WORKS

Here's what we know about vitamin E, and why we chose to build around it.

  • Already in your body

    Vitamin E is a fat-soluble antioxidant your body uses every day to protect cells from oxidative stress.

  • The studied dose

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  • Real research

    Vaginal vitamin E was evaluated across multiple randomized controlled trials in a 2022 systematic review.

  • You're not alone

    Up to 50% of postmenopausal women experience genitourinary syndrome of menopause. Most never talk about it.
References
  1. 1.

    Traber MG, Atkinson J. Vitamin E, antioxidant and nothing more.Free Radic Biol Med.2007;43(1):4–15.

  2. 2.

    Emamverdikhan A, et al. A survey of the therapeutic effects of vitamin E suppositories on vaginal atrophy in postmenopausal women.Iran J Nurs Midwifery Res.2016;21(5):475–481.

  3. 3.

    Porterfield L, et al. Vaginal vitamin E for treatment of genitourinary syndrome of menopause: A systematic review. J Menopausal Med. 2022;28(1):9–16.

  4. 4.

    Portman DJ, Gass ML. Genitourinary syndrome of menopause.Menopause.2014;21(10):1063–8.

WHAT'S INSIDE

The Active

Vitamin E

Vitamin E is a fat-soluble antioxidant the body uses to protect cells from oxidative stress.

We use natural d-alpha-tocopherol, the bioactive form, chosen for its purity and compatibility with sensitive tissue. Each insert delivers 100 IU, 2.5x the dose of our original formula and the same amount used in published clinical research.

The Base

Our Plant-Based Formula

Not all suppository bases are the same.

We use a carefully selected plant-based base, derived from palm kernel oil, chosen for its purity, consistency, and performance. Its more controlled melt at body temperature helps create a cleaner, less messy experience, especially overnight.

What to expect.

No magic, no miracle promises. Just a simple rhythm of consistent, gentle hydration, and a formula designed to let your body do what it already knows how to do.

  • 1

    Insert before bed. The suppository melts at body temperature and releases vitamin E directly at the site while you sleep.

  • 2

    Vitamin E integrates into cell membranes, where it acts as an antioxidant to support tissue integrity.

  • 3

    Localized moisture and comfort support is provided, in line with outcomes observed in 12-week clinical research.

  • 4

    Use 4 to 5 days per week or as needed. Do not exceed 1 insert per day.

1 Traber MG, Atkinson J. Free Radic Biol Med. 2007;43(1):4–15.

2 Emamverdikhan A, et al. Iran J Nurs Midwifery Res. 2016;21(5):475–481.

Not intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before use if pregnant, nursing, or if you have a medical condition.

Trusted by OB/GYNs

As a Board Certified OB/GYN specializing in perimenopause/ menopause care, I prioritize high quality, hormone-free intimate wellness options for my clients. I thoughtfully incorporate NewLife Naturals formulations alongside certain in-office procedures as part of the overall care experience I provide.

Dr. Leslie Bender-Ralph, MD, FACOG, MSCP
Board-Certified OB/GYN and Cosmetic GYN Surgeon GYN Solutions & Aesthetics in Tampa & St. Petersburg

From Real Women. In Their Words.

  • "It's true — this product is just as good as the ridiculously expensive brand, and you get more inserts too. On a blind test, I couldn't tell them apart. I highly recommend this product. It really works well."

    Donna D.
    Verified Buyer

  • "These have been a game changer. The prescription brand I was using was very expensive. My gynecologist recommended I try an OTC suppository to save money — now I'm not even using the script! My body is sensitive to certain products, but I've had no reactions to these."

    Beth
    Verified Buyer

  • "Finally, a product that works like it says it does. What a huge difference. I wish I'd known about this 10 years ago — atrophy is horrible and very painful. This has really helped."

    Cindy L.
    Verified Buyer
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Many women use ESoothe Ultra and HA Inserts together, or alternate between them. They work in complementary ways. Hyaluronic acid focuses on hydration, vitamin E on nourishing antioxidant support. Use what your body asks for.

Explore HA Inserts

Frequently Asked Questions

How often should I use ESoothe Ultra?

We recommend using ESoothe Ultra 4 to 5 days per week at bedtime to start, then as needed. Do not exceed 1 insert per day. Many women notice improvements within a few weeks, but we recommend giving it 8 to 12 weeks of consistent use for full results.

How long does one box last?

Each box contains 24 inserts. With our recommended 4 to 5 day per week use, one box typically lasts about 5 to 6 weeks.

What's the difference between ESoothe Ultra and your original ESoothe?

ESoothe Ultra contains 100 IU of natural vitamin E per insert. That's 2.5x the dose of our original ESoothe formula (38 IU). It's the same clean plant-based base, but formulated for women who want stronger, more noticeable support.

Is it normal to feel slight discomfort when first using ESoothe Ultra?

Some women experience mild sensitivity during the first few uses, especially if tissue is very dry. This typically resolves as your body adjusts. If you're sensitive, try starting with half a suppository, and discontinue use if discomfort persists.

I have very sensitive or dry tissue. Any recommendations?

Yes. For very sensitive or dry tissue, we recommend starting with half a suppository while lying down at bedtime. You can also lubricate the suppository and external area before insertion. Give your body time to adjust over the first week or two before increasing to a full insert.

Can I use ESoothe Ultra if I'm using estradiol or another hormone therapy?

ESoothe Ultra is hormone-free and many women use it alongside estrogen therapy for additional localized nourishment. However, always check with your healthcare provider before combining products, especially if you have specific medical conditions.

My ESoothe Ultra was left in heat. Are they still usable?

If the suppositories have melted or significantly softened, we recommend not using them, as the consistency and shape are important for proper insertion. Store in a cool, dry place below 77°F (25°C). If you received a damaged order, please contact our support team.